Cisco 4200 Series/ISR 4221-A Router Built for SMB Networking

2023 SEASON SALE Networking and Security Showcase In-stock ICT products at exclusive discounts

Cisco announced the end-of-sale and end-of-life date for the most popular Cisco 1941 and 1921 routers. And the Best replacement for Cisco 1941/1921 is the Cisco 4221 Integrated Services Router.

Learn more: Migrate from Cisco 1941/1921 to ISR 4221

The Cisco 4221 Integrated Services Router is the latest addition to the Cisco ISR 4000 Series.

This versatile, value-priced 1RU desktop router provides enterprise-class network performance, services, and security.

The ISR 4221 is many networking tools in one, including:

  • Wireless WAN (3G/4G LTE and Cat6 LTE Advanced)
  • Support for IWAN functionality
  • Wireless LAN
  • Integrated switch ports
  • VRF-aware ‑rewall and NAT
  • Multicore hardware VPN acceleration
  • Network contention control
  • Application services
  • Built-in security
Keeping Your Network Safe

To help protect your branch network and users, the Cisco 4221 ISR provides enterprise-class security features:

  1. IPSec VPN services
  2. Snort IPS
  3. Anomaly detection and machine learning with Cisco Stealthwatch Learning Networks
  4. Cisco Umbrella Branch protection at the DNS layer
  5. Cisco TrustSec
A Technical Triumph for SMB Networking

The Cisco 4221 ISR offers performance and capabilities on par with an enterprise router, delivered in a desktop-sized package that’s ideal for SMB ecosystems:

The Cisco 4221 ISR: Full-Service Networking

Offering the best price-for-performance in its class, the Cisco 4221 ISR is the ideal “Swiss army” router for your network.

The Cisco 4221 ISR enables consistent business-driven and policy-based operations across network domains, including for microbranches, ATMs, kiosks, pop-up locations, and IoT use cases.

Features ISR 4221
Form factor 1 RU Desktop
Integrated WAN Ports GE / SFP


Upgradable to 75 Mbps
Network Interface Modules (NIM) 2
Enhanced Services Modules (SM-X) N/A
Integrated Services Card (ISC) slots N/A
USB Ports (type A) 1
Default/max Flash 8 GB
Default/max DRAM 4 GB
Power supply type External: AC
Redundant power supply No
Module online insertion and removel (OIR) No
Server virtualization platform (UCS E-Series) and Network Compute Engine (NCE) N/A
Zone-based firewall and NAT services VRF-Aware Firewall and Network Address Translation (NAT)
Hardware VPN acceleration(DES, 3DES, AES) Yes
IPSEC VPN services


FlexVPN, Easy VPN remote server, Enhanced Easy VPN, Dynamic Multipoint VPN (DMVPN)
Group Encrypted Transport VPN (GET VPN), V3PN, MPLS VPN
Intrusion prevention Yes (Snort for Singnature Based and FirePower as nGIPS)
Anomaly Detection and Machine Learning Cisco Self Learning Networks (SLN)
Network foundation protection ACL, FPM, control plan protection, control plane policing (CoPP), QoS, role-based CLI access, source-based RTBH, uRPF, SSHv2
Cisco Umbrella Branch Support Yes
Cisco Cloud Web Security Yes
Identity-based networking No
Cisco TrustSec






Security Group Tag Exchange Protocol (SXP), SGT over GETVPN
SGT-based ZBFW
Port/Layer 3 interface/IP/subnet-to-SGT mapping
SGT export in Flexible NetFlow
Local conferencing N/A
Digital signal processor support N/A
Cisco Unified Survivable Remote Site N/A
Telephony support N/A
Cisco Unified Communications N/A
Manager Express support N/A
Cisco Unity Express N/A
(NM, SM, or ISM) N/A
Cisco Unified Border Element (CUBE) N/A
(SIP/H.323 sessions) N/A
nano Cisco Unified Border Element (nanoCUBE) N/A
(sessions) N/A
Digital voice and video (T1/E1 channels) N/A
Analog/BRI voice N/A
IPv4 routing protocols RIP v1/v2, EIGRP, OSPF, BGP, PBR, PfR
Multicast routing protocols PIM-SM, mroute (static route), and MLD
IPv6 routing protocols


Integrated 802.11 b/g/n access point N/A
Integrated 802.11 a/b/g/n access point N/A
Unified and autonomous mode N/A
RP-TNC connectors for field-replaceable N/A
optional high-gain antennas N/A
Diversity (dual antennas) N/A
Wireless LAN controller module N/A
3G /4G LTE cellular Yes
Cat 6 LTE Advanced Yes†
GPS Support Yes
Indoor Antenna Yes (Various antenna using 2 x TNC connectors supporting MIMO)
Outdoor antennas N/A
Maximum switched Ethernet ports 2 x 8
Maximum switched Ethernet LAN ports with PoE 0
PoE support (wattage) N/A
PoE support (wattage) N/A
EtherSwitch Service Module type (width) N/A
Intelligent Path Control PfR
SD-Access Yes
Network Contention Control QoS, HQoS
Application Visibility NBAR v2
WAN Optimization N/A
Akamai Connect N/A
Cisco Application Centric Infrastructure Application Policy Infrastructure Controller (APIC) with Enterprise Module
ISR4221/K9 priced at just $590 USD now (List Price: US$1,195, 51% OFF).
ISR4221-SEC/K9 priced at just $1,152 USD now (List Price: US$2,095, 45% OFF)
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